IL12RB1 CHO
CBP74685
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| I. Background | |
| IL12RB1(白细胞介素-12受体β1亚基)是I型跨膜蛋白,作为IL-12和IL-23受体复合物的共用信号亚基,主要表达于T细胞和NK细胞表面。它顺利获得结合IL-12或IL-23,激活JAK-STAT通路,在Th1免疫应答和抵抗分枝杆菌、沙门氏菌感染中发挥核心作用。该基因突变是孟德尔遗传分枝杆菌易感病(MSMD) 最常见的原因,导致对分枝杆菌和沙门氏菌的易感性显著增加。 | |
| II. Description | |
| IL12RB1 CHO 细胞,在 CHO-K1 细胞的基础上,稳定表达 IL12RB1。 | |
| III. Introduction | |
| Expressed gene: | IL12RB1 |
| Host Cell: | CHO-K1 |
| Stability: | 32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
| Freeze Medium: | 90% FBS+10% DMSO |
| Culture Medium: | F12K+10% FBS+ 5 μg/ml Blasticidin |
| Mycoplasma Testing: | Negative |
| Storage: | Liquid nitrogen |
| Application(s): | Binding Assay,FACS |
| IV. Representative Data | |
Figure 1. Recombinant IL12RB1 CHO constitutively expressing IL12RB1. |
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